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Derrick F MacFabe Selected Research

propionic acid (potassium propionate)

1/2020Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats.
1/2019Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder.
2/2015Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders.
2/2015Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats.
12/2014Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders.
7/2012The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders.
2/2011Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder.
4/2010Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
5/2008Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism.
1/2007Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders.

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Derrick F MacFabe Research Topics

Disease

10Autism Spectrum Disorder
01/2020 - 01/2007
4Autistic Disorder (Autism)
01/2018 - 05/2008
2Neurodevelopmental Disorders
12/2014 - 01/2014
2Neuroinflammatory Diseases
07/2012 - 02/2011
1Infections
01/2015
1Inflammation (Inflammations)
01/2014
1Cognitive Dysfunction
10/2011
1Seizures (Absence Seizure)
01/2007

Drug/Important Bio-Agent (IBA)

10propionic acid (potassium propionate)IBA
01/2020 - 01/2007
6Volatile Fatty AcidsIBA
01/2019 - 01/2007
2LipopolysaccharidesIBA
02/2015 - 12/2014
2Phospholipids (Phosphatides)FDA LinkGeneric
07/2012 - 04/2010
1Butyrates (Butyrate)IBA
01/2018
1Anti-Bacterial Agents (Antibiotics)IBA
01/2015
1Neuronal Cell Adhesion MoleculesIBA
01/2014
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2014
1Butyric Acid (Butanoic Acid)IBA
01/2014
1salicylhydroxamic acid (SHAM)IBA
10/2011
1Anti-Anxiety Agents (Anxiolytics)IBA
10/2011
1Gastrointestinal AgentsIBA
02/2011
1acylcarnitineIBA
04/2010
1LipidsIBA
04/2010

Therapy/Procedure

2Intraventricular Infusions
04/2010 - 01/2007